Ozone (O₃) is an unstable gas found in the atmosphere. It consists of three oxygen atoms and is therefore a strong oxidising agent. Medical ozone is generated via high-voltage oxygen conversion. Application methods range from local treatments to rectal insufflation, ozonated water, and autohaemotherapy.
Therapeutically it is mainly used for its antimicrobial and anti-inflammatory properties. Claims include treatment of diverse conditions such as cancer, infections, diabetes, and neurological or inflammatory diseases
Aromatherapy
Aromatherapy entails the controlled use of essential oils that have been extracted from a variety of plant sources. Therapy is usually given via massage, inhalation or a foot- or full-body bath.
In cancer care, aromatherapy is primarily used as a supportive treatment to manage symptoms and adverse effects associated with cancer and its treatment, especially for anxiety, nausea, sleep and some pain. It acts mainly through olfactory/limbic modulation and specific molecular targets.
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L-Carnitine
Carnitine is the generic term for several compounds including L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine. It is a substance occurring naturally in humans, where it is synthesized endogenously in the liver, kidneys, and brain.
Carnitine is naturally present in many foods and most of the daily requirements of L-carnitine is provided through the diet. It is also available as a dietary supplement.
In the context of cancer, L-carnitine has been mainly investigated for alleviating adverse effects of chemo- or radiotherapy treatment.
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Insulin potentiation therapy
In Insulin Potentiation Therapy (IPT) insulin is used alongside conventional chemotherapy. It is claimed that insulin enhances the effects of chemotherapy, enabling a 75–90% reduction in the usual doses of anticancer drugs and thus reducing the risk of adverse effects.
Although some hypotheses have been put forward, the mechanisms of the claimed insulin potentiation of chemotherapy remain unclear and the few published in vitro studies do not help to clarify this.
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Milk thistle (Silybum marianum)
Milk thistle herbal products are made from seeds of Silybum marianum. Milk thistle has a long history of medicinal use, particularly in the treatment of digestive and liver disorders. Claims in relation to cancer are that milk thistle prevents cancer initiation and development, reduces adverse effects of chemotherapy and radiotherapy, and supports the action of some anticancer drugs.
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Acupuncture
Acupuncture involves the insertion of very thin needles into specific points on the skin. According to Traditional Chinese Medicine philosophy, acupuncture balances the flow of energy, or "qi", through pathways in the body. Western medical acupuncture is based on neurophysiological concepts; acupuncture points are needled to stimulate nerves, muscles and connective tissue thus influencing various bodily functions.
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Black cohosh (Actaea racemosa)
Black cohosh (Actaea racemosa, Cimicifuga racemosa) is a medicinal plant belonging to the Ranunculacea family, originating from Eastern North America. Black cohosh rhizome is used primarily for menopausal symptoms, including hot flushes. Women with a history of breast cancer often experience menopausal symptoms as a result of cancer treatments, and thus this herb is of interest.
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Coenzyme Q10
Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant produced by the body. CoQ10 is utilised by cells for growth and maintenance. As CoQ10 is produced naturally in the body, CoQ10 deficiency is rare in the healthy population. Nevertheless, CoQ10 supplements are widely used and have been studied for various health indications. Research on CoQ10 has focused primarily on cardiovascular disease, although it has also been used in the context of cancer for chemotherapy-induced cardiotoxicity, cancer-related fatigue, inflammation and anti-tumour effects. The underlying mechanisms of action are thought to be antioxidant, immunomodulatory and possible anti-inflammatory.
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Fermented wheat germ extract
Fermented wheat germ extract (FWGE) is industrially produced by fermenting wheat germs of the genus Triticum vulgaris with the addition of baker’s yeast (Saccharomyces cerevisiae). The medicinally active substances of FWGE are not yet known.
FWGE has been marketed as a dietary supplement for cancer patients. In the context of cancer, FWGE is believed to increase efficacy of chemo- and radiotherapy, to reduce their adverse effects and to improve quality of life.
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Biofeedback
Biofeedback is a therapeutic technique that helps individuals learn to control physiological functions that are typically involuntary, such as heart rate, muscle tension, and blood pressure.
By employing electronic monitoring devices, biofeedback provides instant feedback on these bodily functions. This feedback supports individuals in making conscious adjustments to improve their health and well-being