Carctol® is an Ayurvedic herbal mixture consisting of eight herbal extracts, which was developed by Dr Nandlal Tiwari in India.
Its promoters claim that it cures cancer and alleviates adverse effects caused by chemo- and radiotherapy. These claims are, however, not supported by evidence, as not a single clinical trial has so far been carried out.
- No clinical trials have assessed the effectiveness of Carctol.
The safety of Carctol® is uncertain. Although there are no safety issues on record for the combination product, adverse events and interactions have been reported for the individual plants it contains.
Barbara Wider, Katja Boehm, CAM Cancer Consortium. Carctol® [online document], August 15th, 2023.
Latest update: August 2023
Next update due: August 2026
Description and background
Carctol® is a mixture of eight powdered herbal extracts developed by the Indian doctor Nandlal Tiwari from Rajasthan, India (Carctol home). Tiwari is an Ayurvedic medicine doctor who first started promoting Carctol® in 1968 alongside dietary changes. He investigated the effect of indigenous herbs in the forest of Assam by gathering information provided by the tribes there, developed the herbal mixture and allegedly tested it on cancer patients for over 20 years. Tiwari describes Carctol® as "a gift of timeless knowledge of Ayurveda, the complete science of perfection in life especially to cancer” (About Carctol).
Previously, the official Carctol® website published a list of UK doctors who prescribed Carctol® as an Ayurvedic cancer remedy and Carctol® was only available in Europe through these specific UK doctors (Carctol 2012). However, “Ayurvedic medicine” implies it has a track record of traditional use, which is not the case for Carctol®. The current Carctol® website no longer contains this information. Carctol® is still available over the internet in India (Indiamart website).
No data exist to estimate the use of Carctol® by cancer patients.
Ingredients and quality issues
One capsule of Carctol® contains the following ingredients (Carctol composition):
- Blephapharis edulis
- Piper cubeba Linn
- Smilax China Linn
- Hemidesmus indicus
- Tribulus terrestris
- Ammannia vesicaetoria Linn
- Lepidium sativum Linn
- Rheum emodi wall
No independent analyses of the product are available.
Carctol® is advocated by its promoters to strengthen the immune system, regain physical strength and normal body function over a period of time (About Carctol). It is specially indicated in cancer; the manufacturers claim that “Carctol® is a general healer of all kinds of tumours. It also treats and removes all the symptoms and side effects caused by chemotherapy and radiotherapy”. […] “we have seen 30 to 40% success rate in terminal stage cancer patients … we do not claim to cure or treat any disease. Carctol® is a herbal formulation that can be taken by the patient as a support treatment/supplement” (Carctol FAQ).
The official Carctol® website claims that 1,900 terminal-stage cancer patients were treated with Carctol® by Dr Tiwari between 1985 and 1989. The treatment outcomes are reported in a graph plotting the total number of cases against the percentage of response rate in terms of improvements of symptoms (not specified) categorised by each type of cancer (Success stories). The presented data are inconclusive at best and do not support Tiwari’s claim that 30-40% of patients are cured, particularly as all patients left follow up after 2 years.
In 2004, Dr Rosy Daniel in the UK claimed to have prescribed the herbal remedy to 860 cancer patients before and after chemotherapy (Ebner 2004; Hall 2004). At the time Dr Daniel continued to be in touch with about a quarter of these patients and claimed their cancers had not progressed or in some cases have shrunk or disappeared, although she had not audited the patients. Again, none of these claims have been published in the scientific literature.
Application and dosage
According to the Carctol® Dr Nandlal Tiwari Pharmaceuticals website, the recommended daily dosage of Carctol® for adults is between 3-4 capsules. It is supposed to be taken by emptying the contents of capsule & mixing it in ½ cup of lukewarm milk or ½ tsp of honey, or as recommended by healthcare professional. The patient should avoid all sour things while consuming Carctol®. Additionally, patients are advised to drink “pre-boiled and then cooled water” as much as possible. As per the Carctol® website the “ideal judgement period is 60-90 days (Carctol FAQ).
Mechanisms of action
Promoters of Carctol® claim that it “works on the body at cellular level but do not provide further information” (Carctol FAQ)
No current information on the regulatory status of Carctol® could be found. Previously, Carctol® had been classified as an unlicensed medicine by the Medicines and Healthcare products Regulatory Agency (MHRA).
Costs and expenditures
The cost of Carctol® are only available upon request (Indiamart website). Previously, a month’s supply of Carctol® has been indicated at around 120 USD including shipping, minimum six bottles are shipped (personal communication Indiamart representative, 2023). The time span recommended for using the product initially is three months.
The only article published in the scientific peer-reviewed literature is a review from 2009, which did not find any studies on Carctol® and concluded that “the claim that Carctol® is of any benefit to cancer patients is not supported by scientific evidence (Ernst 2009). No published clinical trials, case reports or pre-clinical studies of Carctol® could be found in subsequent literature searches.
The Carctol® website states that “Carctol® has been subjected to in-vitro study at the Advanced Cancer Research Center of TATA, Mumbai against 14 types of human cancer cells out of which it was found effective against pancreatic and lung cancer” (Carctol clinical tests). However, no results have been published in the literature or on the website.
The safety of Carctol® has not been systematically assessed. The distributors of the remedy claim that Carctol® is not associated with adverse effects or herb-drug interactions but these claims are based on the misconception that “obtained and made from completely natural resources, it [Carctol] can never cause any harm or side effects"(Carctol FAQ; NMD 2023). These do not necessarily refer to the dosages used in Carctol®.
No adverse effects of Carctol® have been reported. The official Carctol® website refers to reports of laboratory-based toxicological testing in mice and rats at the All India Institute of Medical Sciences, which shows no risk of toxicities, as well as a certificate of analysis from the Lyne, Martin and Radford laboratories in London, UK (available upon request through the website) However, no pre-clinical study assessing the toxicity of Carctol® has been published in the medical literature.
One of the ingredients of Carctol®, Rheum emodi, has been associated with GI discomfort and uterine contractions. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. When consuming Hemidesmus indicus in excessive amounts, gastrointestinal (GI) irritation or temporary kidney impairment may occur due to its saponin constituents. Orally, ingesting large amounts of Lepidium sativum may cause GI irritations. Piper cubeba and Tribulus terrestris can have psychoactive effects (NMD 2023).
Hemidesmus indicus may interact with heart medication as it may increase digitalis glycoside absorption. Theoretically, due to reports that Piper cubeba increases stomach acid, it might decrease the effectiveness of antacids and proton pump inhibitors. Theoretically, Tribulus terrestris might enhance the blood glucose-lowering effect of hypoglycaemic drugs. Concurrent use of Rheum might decrease mineral absorption. Overuse might cause potassium depletion, increasing the risk of cardio toxicity and digoxin toxicity (NMD 2023).
Patients are advised to drink large amounts of water each day. There is no data on the use of Carctol® during pregnancy and lactation.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. Carctol home, accessed 15th August 2023.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. Carctol composition, accessed 15th August 2023.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. Carctol – frequently asked questions, accessed 15th August 2023.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. About Carctol, accessed 15th August 2023.
Carctol previous website, last accessed on 08th May 2012.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. Success stories, accessed 15th August 2023.
Carctol Official Website, Dr Nandlal Tiwari Pharmaceuticals. Clinical tests, accessed 15th August 2023.
Ebner S. Dr Daniel's 'miracle' cure. The Guardian, 21 September 2004, accessed 24th June 2021.
Ernst E. Carctol: profit before patients? Breast Care 2009;4:31-3.
Hall C. I’ve seen herbal remedy make tumours disappear, says respected cancer doctor. The Telegraph, 20th September 2004, accessed 24th June 2021.
Indiamart website, accessed 15th August 2023.
NatMed. Carctol. Natural Medicines Commercial Products Database (requires subscription), accessed 12th September 2023).