Fermented wheat germ extract
Abstract and key points
- Fermented wheat germ extract (FWGE) is produced from wheat germs of the genus Triticum vulgaris.
- The active ingredient in FWGE is not yet known.
- It has been claimed that orally used FWGE offers beneficial effects for cancer patients during chemo- and/or radiotherapy.
- The evidence from clinical trials to support claims of efficacy is weak.
- The oral intake of FWGE seems to cause no harm.
Fermented wheat germ extract (FWGE) is industrially produced and in clinical use. The production of FWGE involves fermenting wheat germs of the genus Triticum vulgaris by adding baker’s yeast (Saccharomyces cerevisiae). The medically active substances of FWGE are not yet known.
It has been proposed that 2,6-dimethoxy-p-benzoquinone and 2-methoxy benzoquinone found in wheat germ might act antiproliferative because of its high redox potential. FWGE is believed to increase efficacy of chemo- and radiotherapy, to reduce its side effects and to improve quality of life.
Although eight controlled clinical trials consistently reported positive results, the evidence for the claimed benefits is very weak, due to high risk of bias in trials published to this date. No placebo-controlled trials have been carried out.
There is no toxicity known by the intake of FWGE. Side effects are rare and mild.
CitationAlexander Kalisch, Markus Horneber, CAM-Cancer Consortium. Fermented wheat germ extract [online document]. http://cam-cancer.org/The-Summaries/Dietary-approaches/Fermented-wheat-germ-extract. February 8, 2017.
Assessed as up to date in February 2017 by Barbara Wider.
Assessed as up to date in April 2016 by Barbara Wider.
Assessed as up to date in January 2015 by Barbara Wider.
Assessed as up to date in August 2013 by Barbara Wider.
Fully revised and updated in June 2012 by Alexander Kalisch and Markus Horneber.
Summary first published in February 2011, authored by Alexander Kalisch and Markus Horneber.
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